Brain neurogenic areas

This study reports the first isolation and characterization of neural progenitor and stem cells from the adult brain. Neural progenitor and stem cells were isolated from mouse striatal tissue containing the subventricular zone (a neurogeneic area of the adult brain) and cultured in vitro in the presence of epidermal growth factor. 

To study the functional implication of such observations, Santarelli et al. (2003) aimed at determining if an increase in neurogenesis is required for the effect of antidepressants. X-ray irradiation of the hippocampal area in adult rats causes long-term reduction in cell proliferation in the DG (Tada et al., 2000). Hippocampal x-ray irradiation, but not irradiation of other brain areas - like the SVZ or the cerebellar region - prevented the neurogenic effect... 

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