Optimal brain damage

Le Cun, Y., Denker, J. Solla, S. (1990b). Optimal brain damage. Adv Neural Inf Process Syst 2, 598-605. 

Recently, a WHO technical consultation group met to review the maternal iodine requirements during gestation (Benoist et al, 2007). Consideration was given to the fact that the amount recommended should be sufficient to prevent brain damage or thyroid function disorders due to iodine deficiency during pregnancy. There is a lack of data to indicate an optimal intake. Therefore, conclusions were reached after evaluation of the efficiency of gut absorption of iodine, the estimated metabolic needs, and the typical daily losses in the feces and urine. 

Y. LeChun, J. S. Denker, and S. A. Solla, in Advances in Neural Processing Systems 2 (NIPS 2), D. S. Touretzky, Ed., Morgan-Kaufman Publishers, San Mateo, CA, 1990, pp. 598-605. Optimal Brain Damage. 

It might be objected that this conclusion is merely a reflection of the imperfect sensitivity of the tests used to detect impairment in the present study. This of course is always possible. Only a minority of neuropy schologists would claim that current methods of assessment are optimal and most would point to the need for further investment in research to improve upon existing methods. Nevertheless, it should also be remembered that similar batteries of tests have succeeded in demonstrating (a) acute impairment in laboratory studies of samples exposed to comparatively low concentrations of solvents, and (b) persistent deficits in clinical groups such as adult alcoholics (Ron, 1977 Tarter, 1975) or children with various forms of brain damage where a comparable question of impairment has been raised. 

SVM-RFE Application of Optimal Brain Damage and Recursive Feature Elimination... 

Nowadays, as the rapid development of data collection techniques, more and more data are collected, and wrapper methods cannot meet the need of rapid data processing. Then, a number of input pruning methods using SVM have been developed. Guyon and his co-workers proposed to use optimal brain damage as the feature evaluation method and combined it with recursive feature elimination to perform gene selection [64],... 

In optimal brain damage (OBD) [43] a criterion,. S, is defined as a variable describing the importance of the i - th feature... 

There are multiple mechanisms known to underlie the neuronal cell damage associated with injury or disease that at least theoretically could be targeted for pharmaceutical intervention. Currently however, there is no clinically available therapeutic agent that can reliably protect the brain from progressive neurodegenerative processes for sustained periods. Due to the extensive amount of preclinical research that has been conducted in recent years, there is a basis for optimism, however, it appears likely that some of these approaches will result in clinically effective therapeutic modalities in the near future. A short overview of some of the investigational approaches to combat neurodegeneration appears below. 

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