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Bovine corneal opacity

Gautheron, P.D. and Sina, J.F. (1990). The bovine corneal opacity, an in vitro assay of ocular irritancy. Toxicologist 10 258. [Pg.681]

Sina, J.F. Validation of the bovine corneal opacity-permeability assay as a predictor of ocular irritation potential. In Vitro Toxicol. 1994, 7 (3), 283-290. [Pg.1427]

As described by Gautheron P, Dukic M, Alix D, and Sina JF (1992) Bovine corneal opacity and permeability test An in vitro assay of ocular irritancy. Fundamentals of Applied Toxicology 18(3) 442-449. [Pg.2712]

The Bovine Corneal Opacity and Permeability Test Method... [Pg.173]

The Bovine Corneal Opacity and Permeability test method (BCOP) is based on normal physiological and biochemical function of the bovine cornea in vitro. For the BCOP, the eyes are taken from animals slaughtered for human consumption. In this test method (OECD Test Guideline, TG 437), the damage caused by the test substance is assessed by quantitative measurements of changes in corneal opacity and permeability with an opacitometer or a visible... [Pg.173]

Top-down approach1 Identification of serious eye damage Positive results lead to serious eye damage (GHS Cat. 1) classification Bovine Corneal Opacity and permeability (BCOP) test Validated and adopted (OECD TG 437) Applicable to substances and formulations. Positive results obtained with alcohols or ketones should be interpreted cautiously due to risk of overprediction. [Pg.174]

Bottom-up approach13 Identification of non-classified test materials Bovine Corneal Opacity and permeability test Validated and accepted0 (OECD TG 437) Applicable to substances and formulations. [Pg.174]

Cooper KJ, Earl LK, Harbell J, Raabe H (2001) Prediction of ocular irritancy of prototype shampoo formulations by the isolated rabbit eye (IRE) test and bovine corneal opacity and permeability (BCOP) assay. Toxicology In Vitro 15 95-103... [Pg.196]

Kolle SN, Kandarova H, Wareing B, Ravenzwaay B, Landsiedel R (2011) In-house validation of the EpiOcular Eye Irritation Test and its combination with the bovine corneal opacity and permeability test for the assessment of ocular irritation. ATLA 39 365-387... [Pg.197]

Eye corrosion Bovine corneal opacity permeability (BCOP) test Ex vivo... [Pg.666]

See other pages where Bovine corneal opacity is mentioned: [Pg.1420]    [Pg.2712]    [Pg.2712]    [Pg.2712]    [Pg.2713]    [Pg.193]    [Pg.193]    [Pg.196]    [Pg.427]    [Pg.434]   
See also in sourсe #XX -- [ Pg.661 ]



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