Bouvardia

Bouvardin (165) as the first compound of this type of cyclic hexapeptide to be isolated from Bouvardia ternifolia belonging to Rubiaceae, was isolated by Cole et al [85]. 

Bouvardin (165), originally isolated in 1977 from Bouvardia ternifolia (Rubiaceae), was the first member of the RA family and its solid state... 

A cyclic hexapeptide, bouvardin (28), isolated from Bouvardia temifolia, shows high cytotoxic properties through inhibiting the division of hamster ovary cells. 

Stems, leaves, and flowers of Bouvardia ternifolia (Rubiaceae) from Mexico were shown to contain cytotoxic and antitumor compounds. Fractionation revealed two cyclic hexapeptides, bouvardin (26) and deoxybouvardin (27) (Fig. 37.8) (Suffness and Cordell, 1985). The antitumor effects of these compounds were attributed to the ability of these compounds to inhibit protein synthesis because of an effect on the 80-S ribosome. Similar compounds have been found to be the antitumor principles of Rubia akane and R. cordi-folia (Suffness and Cordell, 1985). 

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