Bouquet-type molecules

Bouquet -Type Molecules and the Chundle Approach to Molecular Channels... 

The bouquet -type compounds 114 and 115 and related molecules thus form functional ion transfer entities. Further studies are required to ascertain the mechanism of transport and the effects of parameters such as membrane composition, nature of alkali metal ions and concentration of bouquet molecules on the transport rate in order to better describe the mode of action of these compounds. Ion transport by bouquet -type molecules related to 114 and bearing lateral macrocyclic units has been investigated [8.188]. 

Bouquet -shaped molecules based on either a polyether macrocycle [8.205] or a /3-cyclodextrin (/3-CD) [8.206] core, such as 114 and 115 respectively, have been synthesized and their polycarboxylate forms have been incorporated into vesicle bilayer membranes [8.207]. They present structural features suitable for studies of chundle-type molecular channels (1) the functionalized cyclic annulus possesses substrate selection properties (2) it bears axially oriented bundles of oxygen-containing chains, which provide binding sites for metal cations and are long enough for the molecule to span a typical lipid membrane (the overall length with the chains... 

Canceill, J. Jullien, L. Lacombe, L. Lehn, J.-M., (1992) 62. Channel-type molecular structures. Synthesis of bouquet-shaped molecules based on a B-cyclodextrin core Helv. Chim. Acta 75, 791. 

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