Bordetella pertussis lipopolysaccharide

Aluminium phosphate, AIPO4 Aluminium hydroxide, Al(OH)3 Alum, A1K(S04)2.12H20 Calcium phosphate, CaP04 Mycobacterial species Mycobacterial components (e.g. trehalose dimycolate, muramyl dipeptide) Corynebacterium species Bordetella pertussis Lipopolysaccharide... 

The observed adjuvanticity of Bordetella pertussis is largely attributable to the presence of pertussis toxin and lipopolysaccharide (LPS). LPS, a constituent of the cell envelope of Gramnegative bacteria (Chapter 3), essentially consists of polysaccharide moieties to which lipid (lipid A) is covalently attached. 

Bordetella pertussis endotoxin, and with the ultimate hope of correlating structure and biological, in particular immunological, properties of lipopolysaccharides that compose this endotoxin. 

Treg cells are equipped with TLR 4, TLR 5, TLR 7, and TLR 8 receptors. Bacterial LPS (lipopolysaccharide) may act on TLR 4, either directly or not, through APC cells. Indirect stimulation with the use of Bordetella pertussis leads to the release of IL 10 (Higgins et al., 2003), while the use of Candida albicans additionally extends life expectancy of CD4+ CD25+ lymphocytes (Netea et al., 2004)... 

Compounds having GlcNAc a-(l- 4) linked to 2,3-diacetamido-2,3-dideoxy-a-D-mannose, and to the corresponding mannuronic acid, have been made as 2-phenylethyl glycosides to represent spacer group-containing disaccharide fragments of the lipopolysaccharide of Bordetella pertussis. ... 

Ross PJ, Lavelle EC, Mills KH et al. Adenylate cyclase toxin from bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of 7h2 and regulatory T-cells. Infect Immun 2004 72(3) 1568-1579. 

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