Bone-repair material

These sol-gel-derived nano-hybrids have a potential to show flexibility and bioactivity. As the biological and mechanical properties of nano-hybrids can be tailored by selecting the combination of the organic and inorganic components, these nano-hybrids may be a useful design to obtain flexible and bioactive bone-repairing materials. 

Bioactive ceramics have already played an important role in bone repair in the clinical fields because of their ability to bond to living bone. However, the use of these bioactive ceramics is limited because of their brittleness and higher Young s modulus than bone. The combination of ceramic and organic components provides us with a design for novel tissue-repairing materials. The establishment of these techniques promises a novel bone repairing material. 

Hollinger, J. O., and Battistone, G. C., 1986, Biodegradable bone repair materials, Clin. Orthop. Relat Res. 207 290-305. 

A novel approach based on composites of nanoparticular hydroxyapatite (HA) and PEC of CHT/phosphorylated CHT, which were co-cultured with rat OB in vitro, was reported by Li et al. [175]. After implantation of this PEC/HA material into rabbit femur marrow cavities, a promoted OB adhesion, proliferation, and differentiation in vitro was obtained (bioactive). Because PEC/HA is also biodegradable, it is claimed to be a promising bone-repair material. 

T. Zislis et al., Scanning electron microscopic study of In Vitro Toxicity of Ethylene Oxide Sterilised Bone Repair Materials, Interim Report July 87—March 88, Army Inst, of Dental Research, Washington, District of Columbia, USA. 

T. Zislis, S.A. Martin, E. Cerbas, J.R. Heath, J.L. Mansfield, J.O. HoUinger, A scanning electron microscopic study of in vitro toxicity of ethylene-oxide-sterilized bone repair materials. J. Oral Implantology 15(1), 41 (1989)... 

NOVEL Bone-Repairing Materials Bioactive Organic-Inorganic Hybrids... 

Development of new types of deformable bioactive materials is desired for bone repair. A bioactive material which shows mechanical properties analogous to those of human bones and high durability in the body environment can be obtained by controlling not only the compositions but also the structures of sol-gel-derived organic-inorganic hybrids. The hybrid material can be a candidate for a novel bone-repairing material. 

Jiang, L.Y, Li, Y.B., Zhang, L., Wang, X.J., 2009. Preparation and characterization of a novel composite containing carboxymethyl cellulose used for bone repair. Materials Science and Engineering C 29 (1), 193-198. 

Dehydrated CS 20-30 4-6 / / / Bone filler and bone repair material drug/growth factor delivery vehicle [69]... 

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