Bonds glycosidic ether

The reaction conditions applied are usually heating the amine with a slight excess of aldehyde and a considerable.excess of 2d-30hydrochloric acid at 100 °C for a few hours, but much milder ( physiological ) conditions can be used with good success. Diols, olefinic double bonds, enol ethers, and glycosidic bonds survive a Pictet-Spengler reaction very well, since phenol and indole systems are much more reactive than any of these acid sensitive functional groups (W.M. Whaley, 1951 J.E.D. Barton, 1965 A.R. Battersby, 1969). 

Polymer nanocomposites can be synthesized using cellulose in the form of cellulose nanocrystals or CWs. Pure cellulose is a biopolymer, specifically the polysaccharide of D-anhydroglucose units connected through the (1-1,4-glycosidic ether bond [31], as shown in Figure 6.2. 

BBr is a very useful reagent for cleaving ethers, esters, lactones, acetals, and glycosidic bonds it is used to deoxygenate sulfoxides and in the preparation of image-providing materials for photography (5). 

An interesting linker is based on bis(4-hydroxyphenyl)disulfide 3 (Scheme 9.9). Both MPEG and the carbohydrate are linked as ethers, and for removal from MPEG, the linker s disulfide bond is reductively split by propanedithiol. The carbohydrate is freed as a glycoside of 4-hydroxyphenylmercaptan.38... 

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