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Bonded-phase chromatography advantages

Hydrophilic interaction chromatography (HB IC) or aqueous normal-phase chromatography (ANP) refers to the use of polar stationary phases (e.g., bare silica, silica, or polymeric phases with bonded zwitterionic ligands, diol phases) in combination with a mobile phase rich in organic solvent but containing a significant amount of water (typically at least 3%). Bell [97] summarized the advantages of this technique as follows ... [Pg.344]

The influence of the bonded organic moiety on solute retention has not yet been elucidated and only a very small number of papers discuss the properties and use of such phases so far. The numerous advantages of chemically bonded phases make the application of polar chemically bonded phases with nonpolar eluents quite attractive even if the standardization of these phases may pose problems 106) similar to those encountered in the standardization of aidsorbents as well as of polymeric liquid phases in gas chromatography. A detailed discussion of the properties and chromatographic use of bonded stationary phases is given by Melander and Horvath (this volume). [Pg.57]

The growing popularity of reversed phase chromatography in particular has prompted polymer manufacturers to investigate the use of polymeric media for this mode of operation. Macroporous copolymers of styrene and divinylbenzene have similar properties to silica based stationary phases bonded with alkyl chains. However, the absence of leachables and stability at high pH can offer advantages under certain circumstances. High quality, mechanically stable macroporous polymeries are now manufactured at much larger scales than the... [Pg.10]

Though many of the applications of LLC are now carried out more conveniently using bonded phase techniques the method has some advantages which make it a useful adjunct to the other modes of column chromatography. The major benefits derive from the ease of renewal of the stationary phase, the degree of selectivity that can be achieved (as a wide range of liquids can be selected for the stationary phase) and the reproducibility of the chromatography. [Pg.317]

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See also in sourсe #XX -- [ Pg.665 ]



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