Body temperature clinical evidence

In the 1950s, a more evidence-based approach to antipsychotic drug (AP) therapy was undertaken when structural variations of antihistamines were produced by a French scientist (Paul Charpentier), in order to make use of the unwanted sedative side effect produced by these drugs. Initially used to lower body temperature in patients undergoing cardiac surgery, chlorpromazine (Fig. II) was the first drug with antipsychotic properties successfully used in clinical trials [3],... 

CLINICAL EVIDENCE FOR THE IMPORTANCE OF BODY TEMPERATURE IN STROKE... 

In humans, sepsis can follow pulmonary and nonpulmonary infections, and ARDS can occur in either clinical setting (reviewed in ref. 5). Sepsis is defined as the systemic response to a definite or probable tissue infection, and typically includes changes in body temperature, blood leukocyte counts, hemodynamic parameters, and organ function (6). There is an important distinction to be made between bacteremia, defined simply by a positive blood culture, and sepsis, which includes a specific systemic response. Most cases of bacteremia are not associated with clinical evidence of sepsis, and bacteremia by itself is rarely associated with ARDS (7). Rather, it appears that a primary tissue infection is an important requirement for the onset of sepsis in humans, and an important antecedent for ARDS whether or not bacteremia is detectable (8). 

It is rare for stents to expand to their full diameter immediately. At the end of the procedure most stents will have opened to about 50% of their nominal diameter at the site of the lesion and will continue to expand for 2-3 days after delivery. This particularly applies to nitinol stents, which only develop their full radial force after warming to body temperature. If considered appropriate, balloon dilatation can be used to open the stent further but this carries with it the risks of stent displacement and perforation and is generally not necessary. Stents constructed from individual segments rather than woven from a single strand of wire shorten less, but may look very distorted when released. Again these will reconfigure over the space of 24-48 h (Fig. 11.8e,f) and further intervention should be resisted unless there is clinical evidence of poor function. 

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