Blues antitumor activity

VII. Antitumor Active Platinum-Blue Complexes References... 

Pinacolone, o-(diphenylphosphino)benzoyl-coordination chemistry, 401 Piperidine, IV-hydroxy-metal complexes, 797 pA a values azole ligands, 77 Plant roots amino acids, 962 carboxylic acids, 962 Plastocyanin copper binding site, 557 copper(II) complexes, 772 copper(II) site in, 770 Platinum, dichlorobis(benzonitrile)-IR spectrum, 264 Platinum, cis-dichlorodianunine-antitumor activity, 34, 979 Platinum, ethylenebis(triphenylphosphine)-reactions with 5,6-dimethyl-2,l,3-benzothiadiazole, 194 Platinum blue formation, 265 Platinum complexes acetylacetone reactions, 380 amides, 491 amidines... 

Much of the Pt2n chemistry came about as a result of the serendipitous discovery of the first platinum pyrimidine blue , formed from cis-[Pt(NH3)2(H20)2]2+ and polyuracil left incubating for several days at pH 7 and 37 °C. This material proved to have high antitumor activity as well as low renal toxicity [1-4], However, interest in Ptin chemistry [5-10] also arises from its possible occurrence in mixed-valence one-dimensional materials [11] [12] and from the participation of Ptm in Ptn/PtIV redox processes [13], as well as in the photocatalytic activation of C-M and C-X bonds [14],... 

Since the discovery of the antitumor activity of m-PtCNFhuC (cisplatin, cd-DDP) by Rosenberg et al. [1], the interactions of cisplatin with nucleotides and nucleobases have attracted attention towards gaining an understanding of the mechanism of the antitumor activity of cisplatin at a molecular level. In the course of such studies, dark-blue platinum complexes called platinum blues were obtained when hydrolysis products of cis-... 

Phenazinomycin, also having a deep blue color, is an antibiotic produced by Streptomyces sp. WK-2057. This antibiotic showed cytotoxicity against HeLa S3 cells (MIC, 0.8 pg/ml) in vitro and antitumor activity against S180 implanted mice (ITS, 130%, 22.2mg/kg/day x 9, ip) in vivo [2,3]. 

Significant to the development of rationale chemotherapy was the systematic study of anionic dyes by Paul Ehrlich and his co-workers. Trypanocidal dyes, such as isamine blue, showed clinical antitumor activity which was initially related to stimulation of phagocytic pyrrhol cells. 

The tjipanazoles (18, 19a-d, 20a-b) a group of A-glycosides of indolo-[2,3-a]carbazole, have been isolated from the moderately antifungal extract of the blue-green alga Tolypothrix tjipanasensis. These alkaloids do not exhibit antitumor or protein kinase C (PKC) inhibitory activity, which is in contrast with the... 

General name for antitumor antibiotics with benzo-quinone and aziridine structural units from cultures of streptomycetes (e. g., Streptomyces lavendulae, S. ver-ticillatus, S. caespitosus). There are more than 15 natural variants containing a pyrrolo) 1,2-a)indole system and differing in R and R, with OH in place of OCHj at C-9a, and different stereochemistries at C-9. The violet to blue-violet, optically active M. crystallize readily and are soluble in water, methanol, and acetone. A cluster of 47 bacterial genes that control biosynthesis of M. C has been characterised. The biosynthetic building block of the benzoquinone (C7N) unit is 3-amino-5-hydroxybenzoic acid, several total syntheses have been repotted. 

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