Partition coefficients blood/dialysis water

Deterniination of Blood/Dialysis Water Partition Coefficient... 

To understand the affinity of chlorinated compounds for dialysis fluid and blood as a model for the transfer of a lipophilic organic contaminant to the blood compartment, it is possible to calculate the blood/dialysis water partition coefficient (A b/dw) under static conditions (see Figure 29.2) ... 

Biochemical parameters such as tissue/blood partition coefficients can be obtained from in vitro experiments with vial equilibration (18) or equilibrium dialysis techniques (19). A less expensive process involves exploiting the similarities in physical characteristics of similar tissues in animals and humans and using in vitro animal data (20). Other, even more cost-effective techniques include extrapolation from experimentally determined octanol/water partition coefficients (21), or in sUico parameter estimation via techniques based on structure-property relationships (22, 23). 

FIGURE 29.2 Determination of blood/dialysis water (/fb/dw) partition coefficient. 

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