Blood brain harrier

Ability of chemical to cross the blood-brain harrier. 

P. M. Friden, L. P. Wahis, G, F. Musset M. A. Bylor, B. Malfroy, and R. M. Statzyk. Anti-transferrin ieoeptra antibody and antibody-drug conjugates cross the blood brain harrier. Proc NatL Acad. ScL UU 68 4771-4775 (1991). 

Pollay, M., Roberts, P.A. (1980). Blood-brain harrier a definition of normal and altered function. Neurosurgery 6 675-85. 

Seelig, A. (2007) The role of size and charge for blood—brain harrier permeation of drugs and fatty acids. Journal of Molecular Neuroscience, 33, 32—41. 

Fischer, H., Gottschlich, R. and Seelig, A. (1998) Blood-brain harrier permeation molecular parameters governing passive diffusion. The Journal of Membrane Biology, 165, 201-211. 

Yes. While a-methyldopa may be converted to a-methylnorepinephrine in both central and peripheral adrenergic neurons, the major antihypertensive effect of the drug is in the midbrain. Because carbidopa does not cross the blood-brain harrier, the drug would not affect levels of central a-methylnorepinephrine. 

Peirali, J. P, Maxwell, D. M., Lenz, D. E, and Mills, K, R. (1991). Effect of an anlicholinc-sterase compound on the ultra-siruciure and function of the rat blood-brain harrier A review and experiment. J. SHbmtrTO.se. C.viol. PaihoL 23, 331-3.38. 

Replacement therapy with dopamine itself is not possible in Parkinson s disease because dopamine does not pass Ihe blood-brain harrier. Kowever, its precursor. levod >pa (i. dupa). does penetrate the... 

Rapoport, S.I., 2000. Osmotic opening of the blood—brain harrier principles, mechanism, and therapeutic apphcations. Cell. Mol. Neurobiol. 20 (2), 217—230. 

Hendrikse NH, de Vries EG, Eriks-Fluks L, van der Graaf WT, Hospers GA, Willemsen AT, Vaalburg W, Franssen EJ. A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain harrier. Cancer Res 1999 59 2411-2416. 

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