Pluronic block copolymers, blood-brain barrier

Kabanov, A. Y., E.V. Batrakova, and D.W. Miller. 2003. Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv Drug Deliv Rev 55 151. 

The use of polymeric micelles to deliver drugs to the central nervous system (CNS) has been reviewed recently. One strategy employs polymers with specific ligands to enhance transport across the blood-brain barrier (BBB), via interaction with receptor proteins on the BBB. Many of the polymers employed are derivatives of PEO- PPO PEO block copolymers (Pluronics). 

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See also in sourсe #XX -- [ , ]

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