Antigens blocking

Compound 6 inhibited Syk kinase with K = 0.01 gM, and less potently inhibited Lyn, Fyn, Src, Itk, Btk, PKCot and PKC0 with KjS = 0.75, 2.05, 5.0, >9.5, >10, >15 and >15gM, respectively, and blocked antigen presentation of IC in mouse bone marrow-derived dentritic cells [59]. Inhibition of IL4 production (EC50 = 1.08 gM) was measured to ascertain inhibition of antigen presentation of IC by dendritic cells to T cells. 

Ditzel, H., Erb, K., Nielsen, B., Borup-Christensen, P., and Jensenius, J. (1990) A method for blocking antigen-independent binding of human IgM to frozen tissue sections when screening human hybridoma antibodies. J. Immunol. Meth. 133, 245-251. 

I. Interference with antigen recognition. Muromonab CDS is a monoclonal antibody directed against mouse CD-3 that blocks antigen recognition by T-lymphocytes (use in graft rejection). 

Temple DM, McCluskey M. Loratadine, an antihistamine, blocks antigen- and ionophore-induced leukotriene release from human lung in vitro. Prostaglandins 1988 35(4) 549-54. 

Interleukin-10 (IL-10) is a cytokine produced by activated macrophages, certain lymphocytes, and other cells that decreases both innate and T-ceU-mediated immune inflammation it inhibits the production of cytokines by activated T cells, plays a role in B-cell activation, inhibits production of IFNy, and blocks antigen presentation and macrophage formation of IL-1, IL-6, and TNF. ... 

Gilbert MJ, Riddell SR, Plachter B, Greenberg PD (1996) Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature 383 720-722... 

BG9588 is a humanized anti-human CD40L antibody that blocks antigen-specific IgG responses in non-human primates (baboons and rhesus monkeys) immunized with a variety of T-dependent antigens. It has been studied in humans with lupus glomerulonephritis, but the study was terminated prematurely because of thromboembolic events [104 ]. 

Bourne, H. R., Melmon, K. L., and Lichtenstein, L. M., 1971, Histamine augments leukocyte adenosine 3, 5 -monophosphate and blocks antigenic histamine release. Science 173 743-745. 

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