Bloch. Konrad

Bisphenol A, epoxy resins from, 673 polymers from, 821 Bloch, Konrad Emil, 1084 Block copolymer, 1212 sy nthesis of, 1212... 

Animals accumulate cholesterol from then diet but are also able to biosynthesize It from acetate The pioneering work that identified the key intermediates m the com plicated pathway of cholesterol biosynthesis was carried out by Konrad Bloch (Harvard) and Feodor Lynen (Munich) corecipients of the 1964 Nobel Prize for physiology or... 

Konrad E. Bloch, Feodor Lynen medicine, physiology discoveries concerning mechanism and regulation of cholesterol and fatty acid metabohsm... 

In 1952, Konrad Bloch and Robert Langdon showed conclusively that labeled squalene is synthesized rapidly from labeled acetate and also that cholesterol is derived from squalene. Langdon, a graduate student of Bloch s, performed the critical experiments in Bloch s laboratory at the University of Chicago, while Bloch spent the summer in Bermuda attempting to demonstrate that radioactively labeled squalene would be converted to cholesterol in shark livers. As Bloch himself admitted, All I was able to learn was that sharks of manageable length are very difficult to catch and their oily livers impossible to slice (Bloch, 1987). 

Konrad Emil Bloch (1912-20001 was born in Neisse, Germany, and began his study at the Technische Hochschule in Munich. He then immigrated to the United States in 1936 and obtained his Ph.D. from Columbia University College of Physicians and Surgeons in 1938. After first serving as professor at the University of Chicago, he moved to Harvard University in 1954. He is best known for his work on cholesterol biosynthesis, for which he shared the 1964 Mobel Prize in medicine. 

Konrad Bloch, on how his career turned to problems of lipid metabolism after the death of his mentor, Rudolf Schoen-heimer article in Annual Review of Biochemistry, 1987... 

Work on the biosynthesis of cholesterol began in earnest after Rudolf Schoenheimer and David Rittenberg, at Columbia University, developed isotopic tracer techniques for the analysis of biochemical pathways. In 1941, Rittenberg and Konrad Bloch were able to show that deuterium-labeled acetate (C2H, COO ) was a precursor of cholesterol in rats and mice. In 1949, James Bonner and Barbarin Arreguin postulated that three acetates could combine to form a single five-carbon unit called isoprene. 

Universal discovered by Sir Frederick Gowland Hopkins (UK, shared Nobel Prize, Medicine, 1929, growth stimulating vitamins) enzymatic synthesis studied by Konrad Bloch (Germany/ USA, Nobel Prize, Physiology/ Medicine, 1964, cholesterol biosynthesis)... 

Steroids arc lieavily modifted triterpeues that are btoeyntheaized in orjEftnisms from the acyclic hydrocarbon aqualeiio (SSection 27.6). The-e ci pathway by which thia remarkable transformation is accomplished lengthy and complex, but the key steps have now been worked out, with notable contributions made by Konrad Bloch and John Cornforth, who received hJohcl Prizes for their eiforts. 

Konrad Bloch and Feodor Lynen shared the 1964 Nobel Prize in Physiology or Medicine for unraveling the complex transformation of squalene to cholesterol. 

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