Cautions bleeding syndrome

Since these aromatic substances strongly stimulate the Yin, Yang, Qi and blood, they may scatter and weaken the Qi. Thus they should be applied only for a short period of time. After patients are revived from coma, treatment should be given according to the differentiation of the current syndrome. Caution in pregnancy and bleeding conditions ... 

Other things to consider are the raised INR and low platelet count (avoid drugs that affect coagulation or cause bleeding), the risk of encephalopathy if the liver function decompensates (caution with any drugs causing sedation, constipation, fluid or electrolyte disturbances) and the risk of hepatorenal syndrome (avoid renally toxic drugs). 

Warning/ precautions or contraindications Patients should take medication with food, milk, or antacids. Avoid in patients with active Gl bleed or ulcer disease. Use with caution in elderly patients and patients with severe Gl, renal, or liver disease. Patients should take medication with food or milk to prevent Gl upset. Can precipitate an acute gout attack should avoid use in patients with CrO of < 50 mL/min. Severe skin rashes such as Stevens-Johnson syndrome have been reported. 

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