Bispyridinium monooximes

Sikder et al. (1993) synthesized two new series of 3,3 -and 3,4 -substituted bispyridinium monooximes and two bisoximes bridged by 2-oxapropane (Figure 66.14) and propane (Figure 66.15) connecting chain. 

Consequently, they tested their reactivation activity on tetraethylpyrophosphate-inhibited mouse brain cholinesterases. Their activities were compared with pralidoxime. All the compounds (except that with pentylene bridge) were found to be more effective reactivators than pralidoxime. Bispyridinium monooximes with a 3-carbamoyl group were... 

Binenfeld, Z., Deljac, V., Kamenar, B., and Vickovic, I., Strukture-activity relationship in bispyridinium-monooxime antidotes against soman poisoning, Acta Pharm. Jugosl.,34,195-199, 1984... 

Maksimovic, M., Boskovic, B., Radovic, Lj., Tadic, V., Deljac, V., Binenfeld, Z. (1980). Antidotal effects of bispyridinium-2-monooxime carbonyl derivatives in intoxications with highly... 

Monooxime-monocarbamoyl bispyridinium xylene-linked reactivators (31 Figure 72.25) were prepared by Musilek et al. (2010). The compounds were evaluated on the tabim- and paraoxon-inhibited AChE. Compounds did not exceed previously known data for tabun... 

Musilek, K., Holas, O., Kuca, K., et al., 2008. Synthesis of monooxime-monocar-bamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. J. Enzyme Inhib. Med. Chem. 23, 70-76. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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