Bisphosphonate-bone interaction

Flanagan AM, Chambers TJ. Inhibition of bone-resorption by bisphosphonates—interactions between bisphosphonates, osteoclasts, and bone. Calcif Tissue Int 1991 49 407-415. 

Olejnik, C. et al. (2011) Molecular interaction between bisphosphonates and human bone a preliminary study on osteonecrosis sequesters of the jaw. Bull. Group Int Reck Sci. Stomatol. Odontol, 50 (1), 52-53. 

The affinity of the phosphonates and bisphosphonates to ions led to their application in the treatment of osteoporosis, hypercalcemia, and the inhibition of bone resorption [25]. This property also led to the development of platinum complexes (Fig. 13.7) that have been used to specifically target bone cancer [26, 27]. The bisphosphonate functionality strongly interacts with the bone surface directing the platinum to the tumor. The complexes are active against different cancer cell lines and are more active following addition of Ca " ions and were found to be particularly active against the transplanted osteosarcoma in in vivo studies [28]. 

---