4.4- Bis -l,r-binaphthyl

Castro, P. P. and Diedeiich, F. (1991) Optically Active Mono and Bis(l,r Binaphthyl)-Cyclophanes Large Differences in the Complexation of Naproxen Derivatives in Aqueous Solution , Tetrahedron Lett., in press. 

Chiral crown ethers are synthetic macrocyclic polyethers and were first introduced as CSPs for LC by Cram and co-workers in the late 1970s. In their pioneer works, bis-(l,r-binaphthyl)-22-crown-6 was immobilized on silica gel [126] or polystyrene [127] to resolve a-amino acids and their derivatives. Since then, different chiral crown ether CSPs have been developed and successfully applied in the HPLC separation of enantiomers containing primary amine and secondary amine groups [20, 128-139]. Both dynamically coated [128, 129] and covalently bonded [130-132] chiral crown ether CSPs are commercially available. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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