Isoprenoid biotransformation

Where natural production is not at sufficient titre and biotransformation is not a viable approach, microbes must be engineered to produce the desired isoprenoid directly from central carbon intermediates. Here we will review engineering approaches for isoprenoid production, focusing on model organisms but also discussing more unusual production strains. We also review some of the economic and practical considerations for isoprenoid bioprocesses, including issues related to feedstock price/availability (particularly important for bulk bioprocesses) and product toxicity (particularly for isoprenoid hydrocarbons with fuel applications). 

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