Biotransformation glucuronidation capacity

The level and activity of specific enzymes involved in biotransformation can differ depending on the species, strain, age, and sex of the test animal. For example, cats cannot carry out glucuronidation reactions, newborn rats have relatively low cytochrome P450 activity, and male rats are more sensitive to carbon tetrachloride toxicity than female rats. These differences are important to consider when interpreting the results from toxicological studies. The observation that age, sex, and genetics can significantly influence biotransformation reactions in animals raises the question of whether these characteristics also affect the biotransformation capacity of humans. 

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