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Biotherapeutics potency

Case Study Changes in Potency Caused by Lot-to-Lot Differences in CAMP In this example, THP-1 cells (a human leukemia cell line) were found to be responsive to a biotherapeutic agent in development. The biotherapeutic caused a stimulation of cAMP that accumulated in the cells exposed to drug and could be released after lysing the cells. Therefore, determination of cyclic adenosine monophosphate (cAMP) levels in THP-1 cell culture lysates was used as an indicator... [Pg.250]

See other pages where Biotherapeutics potency is mentioned: [Pg.344]    [Pg.83]    [Pg.87]    [Pg.197]    [Pg.242]    [Pg.251]    [Pg.252]    [Pg.262]    [Pg.262]    [Pg.370]    [Pg.561]   
See also in sourсe #XX -- [ Pg.249 , Pg.252 ]



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Biotherapeutics

Potency

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