Biosynthesis organohalogen compounds

These are of primary signihcance in the biosynthesis of organohalogen compounds (Neilson 2003), which are distributed among mammals, marine biota, bacteria, and fungi. 

Harper DB, O Hagan D, Murphy CD (2003) Fluorinated Natural Products Occurrence and Biosynthesis. In Gribble GW (ed) Natural Production of Organohalogen Compounds, The Handbook of Environmental Chemistry, vol 3, part P. Springer, Berlin, p 141... 

Of the more than 4500 known naturally occurring organohalogen compounds, a large fraction are alkaloids [1,3]. Most of these halogenated pyrroles, indoles, carbazoles, carbolines, tyrosines, and others have a marine origin. The present chapter surveys the occurrence, structure, and biosynthesis of these fascinating natural products. However, given their sheer number, this review focuses mainly on recent examples. 

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