Natural products, fluorinated

The search for nontoxic fluorinated surfactants is shifting from fully synthetic surfactants to perfluoroalkylated natural products. Fluorinated surfactants have been prepared from nontoxic biocompatible intermediates [42,117, 131-133]. Riess and his co-workers [131] at the University of Nice, France, have made perfluoroalkylated surfactants with a modular structure ... 

Harper DB, D O Hagan, CD Murphy (2003) Fluorinated natural products occurrence and biosynthesis. Handbook Environ Chem 3P 141-169. 

D. O Hagan, D.B. Harper, Fluorine-containing natural products, J. Fluorine Chem. 100 (1999) 127-133. 

Biological Impacts of Fluorination Pharmaceuticals Based on Natural Products... 

This present chapter is devoted to the recent advances, for the last decade, in fluorinated analogues of natural products developed as pharmaceuticals and now/ marketed or in development (registered or in clinical development). These mainly concern fluorine-substituted nucleosides, alkaloids, macrolides, steroids, amino acids and prostaglandins. 

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