Bioprocess Measurement and Control

Bioprocess Measurement and Control in Large Scale Culture. 

Measurement and control systems used in the bioreactor for plants are essentially the same as those for microbial or animal cell cultures, but, in special cases, where the mineral components influence the productivity of secondary metabolites, the kind of salts used for the electrode must be taken into consideration. 

Mass balance. The mass balance equation (Eq. 4) is generally used for heterotrophic organisms. Pareilleus and Chaubet (1980)1 have applied the equation to apple cell cultures  

From the equation, w and Fq can be estimated fi om a plot of 1/X- dS/dt) against ju. The values observed for Yq and m are in good agreement with those reported previously by Kato and Nagai (1979)1 calculated from tobacco cell cultures i.e., m values were smaller and Yq values were higher compared to the values reported for many microorganisms. 

Measurement and Mathematical Fitting of Cell Growth. Richards (1960) used a generalized logistic curve for the mathematical fitting of the growth curve of plants. The equation is  

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