Biopolymer helix-coil transition

Theory of helix-coil transitions in biopolymers. (Poland, D., Scheraga, H.A., eds) Academic Press, New York (1970)... 

E Pefferkorn, A Schmitt, R Varoqui. Helix-coil transition of poly(a,L-glutamic acid) at an interface Correlation with static and dynamic membrane properties. Biopolymers 21 1451-1463, 1982. 

Typical examples are the conversion of the neutral form of an amino acid into its zwitterionic form, the helix-coil transitions in polypeptides and polynucleotides, and other conformational changes in biopolymers. Reactions of higher molecularity in which reactants and products have different dipole moments are subject to the same effect (association of the carboxylic acids to form hydrogen-bonded dimers). Equilibrium involving ions are often more sensitive to the application of an electric field ... 

Many biological polymers display a cooperative transition from an ordered to disordered state [34] including the helix coil transitions observed for both peptides [35] and nucleic acids [36]. Synthetic systems that are able to undergo a cooperative helix coil transition can complement biopolymer studies and are of potential interest for density-responsive materials. 

Diagrammatic illustration of the helix-coil transitions in biopolymers (top). Helix-monomer transition in associative biocolloids (bottom)... 

Thomas, T.J. and Bloomfield, V.A. (1984) Ionic and structural effects on the thermal helix-coil transition of DNA complexed with natural and synthetic polyamines. Biopolymers, 23, 1295-1306. 

Schwarz, G. Seelig, J. Kinetic properties and electric field effect of the helix-coil transition of poly(gamma-benzyl 1-glutamate) determined from dielectric relaxation measurements. Biopolymers 1968, 6, 1263-1277. 

McCammon JA, Northrup SH, Karplus M, Levy RM (1980) Helix-coil transitions in a simple polypeptide model. Biopolymers 19 2033-2045... 

M. Go and H. A. Scheraga, Biopolymers, 23,1961 (1984). Molecular Theory of the Helix-Coil Transition in Polyamino Acids. V. Explanation of the Different Conformational Behavior of Valine, Isoleucine, and Leucine in Aqueous Solution. 

M. Vasquez, M. R. Pincus, and H. A. Scheraga, Biopolymers, 26, 351 (1987). Helix-Coil Transition Theory Including Long-Range Electrostatic Interactions Application to Globular Proteins. 

D. Poland and H. A. Scheraga. Theory of Helix-Coil Transitions in Biopolymers Statistical Mechanical Theory of Order - Disorder Transitions of Biological Macromolecules. Academic Press, New York, NY, 1970. 

S. Lifson, Theory of the helix-coil transition in DNA considered as a copolymer. Biopolymers 7 25-32 (1963). 

Gans, P. J., Lyu, P. C., Manning, M. C., Woody, R. W., and Kallenbach, N. R., The helix-coil transition in heterogeneous peptides with specific side-chain interactions Theory and comparison with CD. spectral data, Biopolymers 31, 1605-1614 (1991). 

Roth W, Heidemann E. Triple helix-coil transition of covalently bridged collagenlike peptides. Biopolymers 1980 19 1909-1917. 

Poland, D. Scheraga, H. A. "Theory of Helix-Coil Transitions in Biopolymers" Academic Press New York, 1970. 

Kikuchi K, Yoshioka K. Electric birefringence of poly-L-lysine hydrobromide in methanol-water mixtures and helix-coil transition induced by high electric fields. Biopolymers 1973 12 2667-2679. 

J. McCammon, S. Northrup, M. Karplus, and R. Levy, Biopolymers, 19, 2033 (1980). Helix-Coil Transitions in a Simple Polypeptide Model. 

DiBlasi, R., and Verdini, A. S. (1974). Biopolymers 13, 765. 1 3C Nmr Study of the Helix-Coil Transition of Poly-N5-(30Hydroxypropyl)-L-Glutamine. 

Suzuki, Y., Inoue, Y., and Chujo, R. (1975). Biopolymers 14, 1223. Carbon-13 and Proton nmr Studies of Helix-Coil Transition of Poly(y-Benzyl-L-Glytamate). 

Lukashin, A.V., Vologodskii, A.V., Frank-Kamenetskii, M.D., 1976. Comparison of different theoretical descriptions of helix-coil transition in DNA. Biopolymers 15 1841-1844. 

V. Daggett, P. A. Kollman, and I. D. Kuntz, Biopolymers, 31, 1115 (1991). A Molecular Dynamics Simulation of Polyalanine An Analysis of Equilibrium Motions and Helix—Coil Transitions. 

Interest in electric field effects on macromolecules was appreciably revived when it was found that electric fields are capable of producing structural-conformational changes in biopolymers and membranes. Here, too, optical properties are a convenient indicator of field-induced processes. Initial hints of presumably chemical contributions to field-induced changes in birefringence were reported for DNA solutions of low ionic strength. Dielectric measurements have shown that polypeptides in viscous organic solvents may undergo intramolecular helix-coil transitions in the presence of electric fields. In the meantime there are many reports on field-... 

Blagoi YP, Sorokin VA, Valeyev VA, Khomenko SA, Gladchenko GO. Magnesium-ion effects on helix-coil transition of DNA. Biopolymers. 1978 17 1103-8. 

Order-disorder transformation phenomena associated with macromolecules in solution are well-known examples include biopolymers such as polypeptides and DNA [96], 7i-conjugated systems such as the polydiacetylenes [88—93], and tr-bonded systems such as the poly silanes [97]. A detailed theoretical picture of the helix-coil transition in the biopolymers has been developed. Attempts toward a detailed theoretical understanding were made and possible schemes for the observed chromism in such systems were proposed as summarized in Figure 8.24. 

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