Biopharmaceutics oral absorption

Sinko PJ, Lee YH, Makhey V, Leesman GD, Sutyak JP, Yu H, Perry B, Smith CL, Hu P, Wagner EJ, Falzone LM, Mcwhorter LT, Gilligan JP and Stern W (1999) Biopharmaceutical Approaches for Developing and Assessing Oral Peptide Delivery Strategies and Systems In Vitro Permeability and In Vivo Oral Absorption of Salmon Calcitonin (Set). Pharm Res 16 pp 527-533. 

Since solubility and permeability are the two most important factors influencing oral absorption of drugs, the following biopharmaceutical classification system (BCS) for drug substances, based on the work by Amidon et al.,67 has been recommended by the FDA 68... 

Gershanik, T. and Benita, S. (2000), Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharmaceutics and Biopharmaceutics, 50, 179-188. 

Constantinides, P.P. (1995) Lipid microemulsions for improving drug dissolution and oral absorption physical and biopharmaceutical aspe<88narm. Res., 12 1561-1572. 

Interactional benefits go both ways, but Biopharmaceutics can help pharmacologists determine whether lackluster potency is attributable to inherent inactivity or poor oral absorption. 

Dahan, A. and Hoffman, A. (2007) The effect of different lipid based formulations on the oral absorption of lipophilic drugs the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. European Journal of Pharmaceutics and Biopharmaceutics, 67 (1), 96. 

Wright, J.D., Ma, T., Chu, C.K. and Boudinot, F.D. (1996) Discontinuous oral absorption pharmacokinetic model and bioavailability of l-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uradl (l-F MAU) in rats. Biopharmaceutics ei Drug Disposition, 17 (3), 197-207. 

Interestingly, increasing solubility is a pharmacokinetic as well as a pharmaceutical objective. Indeed, and as made explicit in the Biopharmaceutics Classification Scheme (BCS) [24], solubility is one of the main factors influencing oral absorption and hence oral bioavailability. 

Biopharmaceutics is the process of determining the best form for use in the study of the molecule in toxicological and clinical studies and also the most stable preparation for dispensability as a chug product. The pharmaceutical development of chug candidates is an important step that must go on in partnership with the study of pharmacokinetics. Ideally, the oral absorption of the molecular substance in capsule form should be equal to or greater than its absorption when... 

Sinko, P. J., et al. (1997). Oral absorption of anti-aids nucleoside analogues 3. Regional absorption and in vivo permeability of 2 3 -dideoxyinosine in an intestinal-vascular access port (IVAP) dog model. Biopharmaceutics Cf Drug Disposition, 18(3), 697—710. 

Yu, L. X., Lipka, E., Crison, J. R., Amidon, G. L., Transport approaches to the biopharmaceutical design of oral drug delivery system prediction of intestinal absorption, Adv. Drug Deliv. Rev. 1996, 19, 359-376. 

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