Biopharmaceutics Classification System prediction

Fig. 7.5. The Biopharmaceutics Classification System (BCS) provides a scientific basis for predicting intestinal drug absorption and for identifying the rate-limiting step based on primary biopharmaceutical properties such as solubility and effective intestinal permeability (Pefr). BCS serves as a product control instrument. The BCS divides drugs into four different classes based on their solubility and...

It has recently been proposed that the Biopharmaceutical Classification System (BCS) can be used to predict intestinal drug disposition with regards to efflux transport and metabolism (339). Furthermore, on the basis of the key substrate BCS-related properties, permeability, and solubility, the system may be used to predict potential interactions mediated through changes in efflux and/or metabolism at the level of the intestine. 

Using the Biopharmaceutics Classification System (BCS) to Assist in the Prediction of the Clinical Significance of CYP-based and Transporter-based DDIs 320... 

Golovenko NYa, Borisyuk lYu (2008) The biopharmaceutical classification system-experimental model of prediction of drag bioavailability. Biochem Suppl Series B Biomed Chem 2(3) 235-244... 

Figure 10.8 Predictability of systemic exposure profile using a PBPK approach and Biopharmaceutics Drug Disposition Classification System (adapted from Wu and Benet [24]).

Wu, C.Z. and Benet, L.Z. (2005) Predicting drug disposition via application of BCS transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research, 22, 11-23. 

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