Biomembranes, transport

Bioactivity may result directly from step 2 b or from step 3. In the case of bioactivity in a mammal transport may involve crossing of a number of biomembranes. Transport is much simpler in the case of single cells. In the study of pure enzymes, step 1 vanishes. Obviously, interpretation of a QSAR will depend on the type of biocomponent in the biological system which is studied. As the pure enzyme is the simplest system, it is the easiest to interpret. 

Van Winkle, L. J. (1999) Biomembrane Transport, Academic Press, San Diego, California... 

Van Winkle LJ. Biomembrane transport. San Diego Academic Press 1999. 

Tubbs, P. and Ramsay, R. (1979) In Function and Molecular Aspects of Biomembrane Transport (Quagliariello, E., Palmieri, F., Papa, S. and Klingenberg, M., eds.) pp. 279-286, Elsevier Biomedical Press, Amsterdam. 

E Kinne-Saffian, RKH Kinne. Membrane isolation strategy, techniques, markers. In S Fleischer, B Fleischer, eds. Biomembranes Transport Membrane Isolation and Characterization. New York Academic Press, 1989, vol. 172, part 2, pp 3-17. 

Complex formation between an ion with a neutral ligand plays an important role in biomembrane transport, liquid-liquid membranes, and ion-selective electrodes and in liquid-liquid extraction as well. For an example, we consider the system ... 

From the basic parameters initial concentration of ions, their standard transfer potential, distribution coefficients for neutral components, equilibrium constants of reactions taking place in the system, volume of phases, and temperature, a unique general problem for the Galvani potential difference and distribution concentration of all components was established. A numerical solution to the problem with the help of computer program EXTRA.FIFIl provided a good means for quantitative investigation of the liquid-liquid interface. It is also useful for the study of liquid-liquid extraction, electroextraction, voltammetry at interface of two immiscible electrolyte solutions (ITIES) [15,18], liquid-liquid membrane ion-selective electrodes, biomembrane transport, and other fields of science and engineering. 

Duszynski, J., Bogucka, K., Letko, H.G., Kuster, U. and Wojtczak, L. (1979) in E. Quagliaricllo, S. Papa, F. Palmieri and M. Klingenberg (Eds.), Function and Molecular Aspects of Biomembrane-Transport, pp. 309-312, EIsevier/North-Holland, Amsterdam. 

Pande, S. V, and Parvin, R. (1979). In "Function and Molecular Aspects of Biomembrane Transport" (E. Quagliariello, M. Klingenberg and F. Palmieri, eds.), pp. 287-290. Else-vier/North Holland Biomedical Press, New York. 

Koryta, J., L.Q. Hung, and A. Hofmanova (1982). Biomembrane transport processes at the rriES with an adsorbed phospholipid monolayer. Stud. Biophys. 90, 25-29. 

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