Biomedical polyurethane development

D.G. Duguay, R.S. Labow, J.P. Santerre, D.D. McLean, Development of a mathematical model describing the enzymatic degradation of biomedical polyurethanes. 1. Background, rationale and model formulation. Polym. Degrad. Stab. 47, 229-249 (1995)... 

Other synthetic polymers that have been utilised in the development of biomedical nanofibrous structures include the nonbiodegradable polyurethane (KhU et al., 2003 Kim et al., 2009 Verreck et al., 2003) and biodegradable polydioxanone (Kalfa et al., 2010). 

D Annis, T V How, A C Fisher, Recent Advances in the Development of Artificial Devices to Replace Diseased Arteries in Man A New Elastomeric Synthetic Artery. In Polyurethanes in Biomedical Engineering, Planck H, Egbers G, Syre I (Eds), Elsevier Science Publishers B.V. Netherlands, 1984. 

Polyurethanes have had a long history of being developed as biomedical SMPs [95-97]. Typically, the shape-memory properties of thermoplastic polyurethanes... 

The following examples show thermally induced shape-memory. The first three examples are exclusively physically cross-linked. These examples are two polyurethanes representing thermoplastic shape-memory polymers with Ttrans = Tm or Tg, and a high molecular weight, amorphous polynorbornene. Examples of covalently cross-linked shape-memory networks are so-called heat-shrinkable materials and a shape-memory network with a crystallizable switching segment (Ttrans = Tm) that has been developed for biomedical application. 

Sulfopol5miers are employed in biomedical systems. Much effort has been expended to improve blood-contacting biomaterials, eg, segmented polyurethanes, and develop various polysulfates and polysulfonates as antithrombotic or antiviral agents. 

M. Szycher, V.L. Poirier, D.J. Dempsey, Development of an aliphatic biomedical-grade polyurethane elastomer, J. Elastom. Plast. 15 (1983) 81-95. 

Wang WS, Wang C. Polyurethane for biomedical applications a review of recent developments. Design and Manufacture of Medical Devices, WoodheadPubl Rev Mech 2012 115-51. 

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