Bioluminescence imaging tissue optics

Many different non- or minimally-invasive techniques have been investigated for measuring the response of tissues to PDT treatment in vivo, either qualitatively or quantitatively, as summarized in Table 2. To date these techniques have mainly been applied in preclinical animal model studies, but there are a number of examples in the literature where some of the methods have been used in patients. Two of the optical imaging techniques, namely Doppler optical coherence tomography (DOCT) and bioluminescence imaging (BLI) will be illustrated here. 

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