Biologically related catalysis

The related theme of medium effects in biologically related catalysis is reviewed by Marcello Forconi. Although catalysis by enzymes is intimately linked with the aqueous environment, the local environment of the active site is generally accepted to have rather different characteristics, and the impact on key biological transformations is analyzed. Simple medium effects afforded by organic a jegates are explored, leading on to a critical analysis of how these ideas have led to efforts to understand and accelerate the Kemp elimination by artificial enzymes. 

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