Biologically active molecules, nickel-catalyzed

Nickel-catalyzed cross-coupling reaction like the Kumada coupling has been used to form biologically-active molecules. This coupling reaction has been described between fluoroarenes and aryl Grignard reagents with... 

During the past few decades, transition metal-catalyzed cross-coupling reactions have become a powerful tool for the construction of C—C and C-heteroatom bonds [1]. This strategy allows the conceptually simple and yet powerful and reliable approach for synthesizing structurally complex pharmaceuticals and biologically active molecules. The two most vastly used transition metal catalysts in carbon-heteroatom bond formation are palladium (mainly depends on its ancillary ligands) and copper (depends on the optimization of the catalytic system as a whole copper source, solvent, base, concentrations, etc.). Besides, considerable developments have also been made with other transition metal catalysts such as nickel, iron, etc. 

---