Biologically active compounds through

Kumar K, Michalik D, Garcia Castro I, Tillack A, Zapf A, Arlt M, Heinrich T, Bottcher H, Beller M (2004) Biologically active compounds through catalysis efficient synthesis of N-(heteroarylcarbonyl)-N -(arylalkyl)piperazines. Chem Eur J 10 746-757... 

Synthesis of Biologically Active Compounds through C=0 Bioreduction 87 OH O... 

Fig. 32.10 Examples of biologically active compounds obtainable through BINAP-Ru-catalyzed hydrogenation of/ -keto esters.

Fig. 32.44 Examples of biologically active compounds and a chiral ligand obtainable through hydrogenation of simple ketones catalyzed by BINAP/chiral diamine-Ru complexes.

Fig. 32.47 Biologically active compounds achievable by Bl-NAP/1,2-diamine— Ru-catalyzed hydrogenation of 2-substituted cyclohexanones through dynamic kinetic resolution.

In this case study, we will start with a known molecule (for example, Corticosterone), use the property estimation features in ProPred [Marerro (2002)] to create free attachments in the molecule (that is, create a backbone). The Backbone is then transferred to ProCamd, where terminated structures will be generated. In this way structures of synthetic candidates of a lead biologically active compound may be identified through molecular design. 

It is evident that flavonoid ingestion, either through the diet or as pure compounds or active principles in phytomedicines, results in the presence of these biologically active compounds in the gastrointestinal tract during a certain period of time. Thus, this system can be considered as the first putative target of flavonoid effects, especially if we consider the results obtained from the different studies which deal with the bioavailability of flavonoids, (extensively reviewed by Hollman and Katan [25]). 

Figure 1.16. Examples of biologically active compounds and chiral diphosphines obtainable viaBINAP-Ru catalyzed hydrogenation through dynamic kinetic resolution.

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