Biological properties of quinuclidines

The main attention of the present review is concentrated on the general chemical properties and peculiarities of quinuclidine derivatives, methods for building up quinuclidine systems (methods for quinuclidine ring closure), methods for substituent introduction in quinuclidine molecules, and biological properties of quinuclidine derivatives. 

Investigation of the biological properties of quinuclidine derivatives has proceeded mainly in two directions (1) natural alkaloids, their synthetic analogs, and reaction products and (2) the pharmacological actions of compounds containing a quinuclidine ring. This review deals with the second aspect only reference has already been made to several reviews devoted to the quinuclidine alkaloids. 

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