Biological enzyme modeling

Measurement of the kinetic rates and surface diffusion of reversibly bound biomolecules at flattened biological and model membrane surfaces and at specifically derivatized glass surfaces (e.g., with immobilized enzymes). 

In the meantime, the intense study of the simpler vesicle systems has unravelled novel, unsuspected physicochemical aspects - for example growth, fusion and fission, the matrix effect, self-reproduction, the effect of osmotic pressure, competition, encapsulation of enzymes, and complex biochemical reactions, as will be seen in the next chapter. Of course the fact that vesicles are viewed under the perspective of biological cell models renders these findings of great interest. In particular, one tends immediately to ask the question, whether and to what extent they might be relevant for the origin of life and the development of the early cells. In fact, the basic studies outlined in this chapter can be seen as the prelude to the use of vesicles as cell models, an aspect that we will considered in more detail in the next chapter. 

Taube, H., Enzyme Models and Enzyme Structure, Brookhaven Symposium in Biology, No. 15 (1962). 

The comproportionation reaction (15) is biologically unimportant and must be prevented in meaningful enzyme models. Accordingly, much effort has been invested in ligand design aimed to sterically inhibit the formation of dinuclear species several successful and significant... 

V Electrode Catalysis versus Enzyme Catalysis Theoretical Modeling of a Biological Enzyme... 

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