Databases, biological, examples

We are attempting to understand the biological significance of the large variations in frequency of putative LDRs, whether between different types of bacteria or archaea, or between pro- and eukaryota. We have carefully studied the literature of more than 90 example proteins selected from our disordered protein databases and found reports on the functions of most of the disordered regions (Dunker et al., 2002). The observed functions and the number of examples in each functional class are given in Table VI. As indicated, four major functional classes were found molecular recognition, molecular assembly or disassembly, protein modification, and entropic chains. 

QSAR studies are a fertile area for ANNs and numerous papers have been published in the field. Katritzky s group has a range of interests in this area, particularly related to compounds of biological importance see for example Reference 6. Some QSAR studies have been on a heroic scale. Molnar s group has used training sets of around 13,000 compounds and a total database containing around 30,000 to try to develop meaningful links between cytotoxicity and molecular descriptors.7... 

Complete sequencing of this peptide requires acquisition of additional tandem mass spectra, preferably MS3 fragmentation, of one of the low-mass y-ions. Because the peptide of interest is derived from a biological source, yet another possibility might be the use of sequence databases, similarly to the previous example. Actually, this approach works very well in this case, allowing identification of the peptide of interest as H-LGEYGFQNALIVR-OH, the 421-433 fragment of bovine serum albumin. 

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