Biological contractile response

The measured biological activity is the tonic contractile response of longitudinal muscle strips of guinea pig ileum. The log(l/EC50) values were used as the dependent variable Y, which is the molar concentration of a DHP derivative necessary to inhibit 50% of the concentration of guinea pig ileum induced by methylfurmethide.24 The full dataset (Table 1) spans nearly six log units. 

Kitazawa, T., Kobayashi, S., Horiuti, K., Somlyo, A.V., and Somlyo, A.P. (1989) Receptor coupled, permeabilized smooth muscle role of the phosphatidylinositol cascade, G-proteins and modulation of the contractile response to Ca. Journal of Biological Chemistry, 254 5339-5342. 

Several other biological actions of oxidized lipids have also been described. Oxidized phospholipids can induce migration and proliferation of smooth muscle cells to form an atherosclerotic cap, which is a factor in the development of vascular lesions (Chatterjee et al., 2004). This corresponds to a phenotypic switching from a contractile to a de-differentiated proliferative ceU type this is now understood to represent a response to injury and can be considered in part as a protective response that attempts to repair the vessel (Spin et al., 2012). Also relevant to atherosclerosis... 

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