Biological concepts mutations

Finally, the linear low-dose extrapolation obviates de facto the concept of a threshold in the dose-response curve. The threshold concept is universally accepted for most other, noncancer toxicity and for many other biological phenomena (e.g., taste thresholds), and many scientists would argue that such thresholds (or practical thresholds ) should apply to the cancer or mutation response due to the undo-lying complexities in toxicokinetics and in the dynamics of DNA damage and repair, immune surveillance, and the variation in the progression of clinical diseases. ... 

---