Biological chemistry biodistribution

Material characteristics such as size, shape, chemical composition, surface chemistry, roughness, and surface functionalizations profoundly influence the interactions that occur at the interface between nanomaterials and biological systems (proteins, membranes, endocytic vesicles, organelles, DNA, and biological fluids). Evidence from the literature suggests that the biodistribution of nanosized carriers to specific sites is mostly dictated by the physicochemical characteristics of... 

J. D. Hoeschele, T. A. Butler, and J. A. Roberts Correlations of Physico-Chemical and Biological Properties with In Vivo Biodistribution Data for Platinum-195m-Labelled Chloroammineplatinum(II) Complexes (Inorganic Chemistry in Biology and Medicine, ACS Symposium Series v. 140, Ed. A. E. Martell) p. 181. ACS, Washington (1980). 

Nanomedicine is a broad scientific area that spans the areas of biology, medicine, chemistry, and engineering. It aims to use nanoscale platforms for the detection and treatment of cancer and other diseases with high sensitivity and improved outcome [6, 9,10]. Improvements in imaging applications, multi-valent tissue-specific binding, redirection of the biodistribution of drugs, and reduced toxicity of chemotherapeutics... 

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