Biological and Physicochemical Modifiers of Endocrine Disrupter Exposure

3 Biological and Physicochemical Modifiers of Endocrine Disrupter Exposure 

Luebke, P. V. Hodson, M. Faisal, P. S. Ross, K. A. Grasman and J. Zelikoff, Fund. Appl. 

Norris, in Vertebrate Endocrinology, ed. D.O. Norris, Aeademie Press, San Diego, 1996, 

A chemical must have certain physicochemical properties to elicit an endocrine disrupting effect. For example, the ability to enter the body and to cross the cell membrane into the cellular medium requires a degree of lipophilicity. Fipophilic potentials may be compared by reference to the chemical s octanol-water coefficient (usually expressed as log K ). This property, together with molecular size and chemical structure, has an important influence on the bioacciimiilation 

Bergeron and J. A. MeLaehlan, Environ. Health Perspect., 1995,103 (suppl. 7), 73. 

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