Biological Activity of Imidazopyridines

4- (o-ClPhCH2NH)-l-Me-IcP, can be used to treat epilepsy, brain infarct, alcohol syndrome, convulsions, and fear state, etc. (83GEP3150486). 

However, the most powerful and versatile activity among all the imidazopyridine-like antimetabolites was shown by 3-DAG 178, its nucleoside 182, and nucleotides. At the start of research, the low solubility of 3-DAG and its salts, similar to that of 1-DAG, impeded the studies. Fortunately, this obstacle was circumvented by the synthesis of 3-DAG mesylate, well soluble in water (84EUP0103417, 85MI3). 

The results obtained with some non-carbohydrate derivatives of 3-DAG and 3-DAA are worth mentioning. For example, the 3-DAG 9-(2-phosphonomethoxy-ethyl) derivative has shown marked activity against L1210 cells leukemia and DNA-containing viruses (93CCC1419). 

9-(2-(5)-Hydroxy-3-nonyl)-3-DAG 654 is an active adenosine deaminase (ADA) inhibitor. This inhibition can prevent the deactivation of adenosine analogues used in clinical practice (94JMC305). 

1-Cyclopentyl-substituted non-carbohydrate analogues of 3-DAAS, like l( )-3-deazaaristeromydn 655, possess an antiviral activity and inhibit adenosylhomocy-steine hydrolase (83USP4387228). 

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Scribner A, Dennis R, Hong J, Lee S, McIntyre D, Perrey D, Feng D, Fisher M, Wyvratt M, Leavitt P, Liberator P (2007) Synthesis and biological activity of imidazopyridine anticoccidial agents part I. Eur J Med Chem 42 1334-1357... 

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