Biological activities distribution

This type of analysis has, for the first time, provided us with a model that predicts what the addition of specific classes of compounds actually offers in a proactive or design sense. There are many related issues that we are also exploring using these concepts. One is how is biological activity distributed over this GaP space This gives us clues as to the relative importance of some of the partitions in the GaP space. With this type of information, decisions can be made as to whether to concentrate more specifically on some partitions that may be well represented already but provide excellent returns against some targets. 

NAPRALERT (Natural Products ALERT) University of Illinois at Chicago STN information on the pharmacology, biological activity, taxonomic distribution, medicine and chemistry of plant, microbial, and animal (including marine) extracts... 

Absorption, metaboHsm, and biological activities of organic compounds are influenced by molecular interactions with asymmetric biomolecules. These interactions, which involve hydrophobic, electrostatic, inductive, dipole—dipole, hydrogen bonding, van der Waals forces, steric hindrance, and inclusion complex formation give rise to enantioselective differentiation (1,2). Within a series of similar stmctures, substantial differences in biological effects, molecular mechanism of action, distribution, or metaboHc events may be observed. Eor example, (R)-carvone [6485-40-1] (1) has the odor of spearrnint whereas (5)-carvone [2244-16-8] (2) has the odor of caraway (3,4). 

Bergmann D, Hinze J (1987) Electronegativity and Charge Distribution. 66 145-190 Berners-Price SJ, Sadler PJ (1988) Phosphines and Metal Phosphine Complexes Relationship of Chemistry to Anticancer and Other Biological Activity. 70 27-102 Bertini I, see Banci L (1990) 72 113-136... 

The Basic Concept of the QSAR Technique. The QSAR technique has been widely employed in modeling biological activities as well as ADME/Tox (absorption, distribution, metabolism, excretion, toxicity) properties. This approach was first introduced by Flansch et al. in 1963, on the basis of linear... 

The lack of a method to determine the spatial distributions of permeability has severely limited our ability to understand and mathematically describe complex processes within permeable media. Even the degree of variation of intrinsic permeability that might be encountered in naturally occurring permeable media is unknown. Samples with permeability variations will exhibit spatial variations in fluid velocity. Such variations may significantly affect associated physical phenomena, such as biological activity, dispersion and colloidal transport. Spatial variations in the porosity and permeability, if not taken into account, can adversely affect the determination of any associated properties, including multiphase flow functions [16]. 

Some effort has been directed toward understanding the growth requirements of the alga of interest, allelopathic alga (13), the optimum salinity (14), the distribution of allelopathic agents (15), and the temperature optimum (16). This paper reviews the approaches taken to separate the allelopathic agents from the other materials and the methods used to characterize the biological activity of aponin from Nannochloris sp. 

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