Biodegradable polyesteramides

A M LIPS andP J DIJKSTRA, University of Twente, The Netherlands 

Poly(ester amide)s are eonveniently synthesized by polycondensation techniques as appUed in the synthesis of polyesters and polyamides. One can choose either to use methods where preformed monomers are condensed, use ring-opening polymerization or combine both methods. The preformed monomers may eontain either ester or amide functional groups and all the possible combinations lead to architectural variations of poly(ester amide)s. The placement of amide and ester 

In this section the synthesis and properties of successively alternating, segmented (block) and random copoly(ester amide)s will be reviewed. To 

The expected fibre forming properties of poly(ester amide)s makes them suitable as bioresorbable medical sutures. Thus poly(ester amide)s based on a diamine and natural metabolites like glycolic- or lactic acid (Fig. 5.3) have been investigated. The properties of die material could be optimized by the use of water soluble diamide-diols to minimize polymer resorption time. To optimize the polymer melting temperature and in-vivo fibre strength retention succinic acid was used as die comonomer (Barrows, 1980). Alternating poly(ester 

3 Poly(ester-amlde)s synthesized from diamide-diols and di-esters or diacid chlorides, x = 2-16 y = 2-5 z = 2-14 Ri = H, CH3 X = OCH3, Cl. 

---

X. Liu, Y. Zou, G. Cao, D. Luo, The preparation and properties of biodegradable polyesteramide composites reinforced with nano-CaCOj and nano-SiO, Mater. Lett. 61 (2007) 4216-4221. 

P.J.A. in t Veld, P.J. Dijkstra, J. Feijen, Synthesis of biodegradable polyesteramides with pendant functional groups. Makromol. Chem. 

Z. Qian, S. Li, Y. He, C. Li and X. Liu, Synthesis and thermal degradation of biodegradable polyesteramide based on e-caprolactone and 11-aminoundeca-noic acid , Polym Degrad Stabil, 2003, 81, 279-86. 

---