Biodegradable polycaprolactone-containing polyurethanes

Biodegradable polycaprolactone-containing polyurethanes seeded with stem cells... 

Poly(lactide-co-Z-caprolactone) is a derivative of polycaprolactone, which is a biodegradable polyester used in the synthesis of polyurethane polymers. Drachman et al. placed stents containing the polymer poly(lactide-co-Z-caprolactone) into pig vascular beds to study the effects of the stent on neointimal regrowth. They reported that the paclitaxel releasing stent was able to curtail vascular intimal regrowth and in-stent restenosis at all the time points they tested from 7 to 180 days [2]. However, in studies conducted in other animals it became apparent that arteries did not heal completely following stent-mediated release of paclitaxel [3],... 

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