Quantum dots bioconjugates

Xing Y et al (2007) Bioconjugated quantum dots for multiplexed and quantitative immuno-histochemistry. Nat Protoc 2 1152-1165... 

Smith AM, Duan H, Mohs AM, Me S (2008) Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev 60 1226-1240... 

Frasco MF, Chaniotakis N (2010) Bioconjugated quantum dots as fluorescent probes for bioanalytical applications. Anal Bioanal Chem 396 229-240... 

Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science, 281, 2016-2018. 

Jaiswal, J. K., Mattoussi, H., Mauro, J. M. and Simon, S. M. (2003). Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47-51. 

Clarke, S. J., Hollmann, C. A., Aldaye, F. A. and Nadeau, J. L. (2008). Effect of ligand density on the spectral, physical, and biological characteristics of CdSe/ZnS quantum dots. Bioconjug. Chem. 19, 562-8. 

Hering, V. R., Gibson, G., Schumacher, R. I., Faljoni-Alario, A. and Politi, M. J. (2007). Energy transfer between CdSe/ZnS core/shell quantum dots and fluorescent proteins. Bioconjug. Chem. 18, 1705-8. 

Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS (2004) Noninvasive imaging of quantum dots in mice. Bioconjug Chem 15 79-86... 

The following sections discuss many of the major particle types and provide bioconjugation options for the coupling of ligands to the surface of functionalized particles. Some additional nanoparticle constructs, including gold particles, dendrimers, carbon nanotubes, Buckyballs and fullerenes, and quantum dots are discussed more fully elsewhere (see Chapter 7 Chapter 9, Section 10 Chapter 15 and Chapter 24). 

Babu, P., Sinha, S., and Surolia, A. (2007) Sugar-quantum dot conjugates for a selective and sensitive detection of lectins. Bioconjugate Chem. 18, 146-151. 

Medintz, I L., Konnert, J.H., Clapp, A.R., Stanish, I., Twigg, M.E., Mattoussi, H., Mauro, J.M., and Deschamps, J.R. (2004) A fluorescence resonance energy transfer-derived structure of a quantum dot-protein bioconjugate nanoassembly. Proc. Natl. Acad. Sci. USA 101(26), 9612-9617. 

Wang Q, Xu Y, Zhao X, Chang Y, Liu Y, Jiang L, Sharma J, Seo DK, Yan H (2007) A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation. J Am Chem Soc 129 6380-6381... 

Wang D, Rogach AL, Caruso F (2002) Semiconductor quantum dot-labeled microsphere bioconjugates prepared by stepwise self-assembly. Nano Lett 2 857-861... 

Dintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005). Quantum dot bioconjugates for imaging, labelling and sensing. Nature Mater. 4 435 146. 

NANOSCALE SENSING ASSEMBLIES USING QUANTUM DOT-PROTEIN BIOCONJUGATES... 

Goldman, E. R., I. L. Medintz, A. Hayhurst, G. P. Anderson, J. M. Mauro, B. L Iverson, G. Georgiou, and H. Mattoussi. Self-assembled luminescent CdSe-ZnS quantum dot bioconjugates prepared using engineered poly-histidine terminated proteins. Anal. Chim. Acta 534, 63-67 (2005). 

Naval Research Laboratory 4555 Overlook Avenue SW Washington, DC, 20375 Chemistry Division/6112 Ph 202.404.3337 (Greg E. Collins) Greg.collins nrl.navy.mil Optical Sciences Division/5611 Ph 202.767.9473 (Hedi Mattoussi) hedimat ccs.nrl.navy, mil www.nrl.navy.mil Laboratory on a chip for explosive detection, quantum dot-protein bioconjugates, biosensors, UAV radar, and much more in basic research. 

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