Biochemical separation processes chromatographic development

Native enzymes, which can spatially and chemically recognize substrate molecules, are powerful catalytic systems in many biochemical processes under mild reaction conditions. The preparation of artificial enzymatic catalysts with the capability of molecular recognition capability, by a molecular-imprinting method, which creates cavities with a similar shape and size to the template molecule in polymer matrices has been developed [1-14]. The technique has been mainly established in the field of analytical chemistry - molecular receptors [15-23], chromatographic separations [24-28], fine chemical sensing [29-33]. All of the methods rely on the selective adsorption of target molecules on imprinted adsorption sites. The number of papers reported per year on molecular imprinting is summarized in Fig. 22.1. 

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