Biochemical response, training

Several Important training variables are known to Influence the magnitude of the biochemical response. These Include the duration of the training program, the Intensity of the exercise effort, the duration of each exercise bout (mlnutes/day), and the frequency of exercise (l.e., days/week). 

It is conceivable that quantitative structure-activity (QSAR) approaches (e.g., TOPKAT see Chapter 7) could be applied to predict response levels for uncharacterized contaminants for use in the HI approach. Further, specific submodels existing (e.g., that for developmental toxicity) could be applied to estimate system-specific response levels for application in the IT D approach. To our knowledge, there are no computer-assisted programs available that can automate the prediction of toxicity for mixtures. Much of the reason may reside in the relative lack of empirical observations and characterizations of chemical interactions. Many QSAR approaches rely on training set approaches to the development of automated programs. Another impediment may be the many examples of the levels, types and biochemical bases for chemical interactions, the intricacies of which would benefit from an automated approach. This area is a useful area for exploration. 

Somani, S.M. and Dube, S.N., Endurance training changes central and peripheral responses to physostigmine, Pharmacol. Biochem. Behav., 41, 773, 1992. 

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