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Biochemical reductions keto acids

In biosyntheses of amino acids from keto acids and ammonia, a biochemical reduction of the imino group takes place. This is the reverse process of the oxidative desamination of amino acids. Part of the keto acids clearly can be derived from carbohydrates. A review by Wieland points out the relationship with phytochemical reduction. [Pg.101]

The cardiomyopathy is directly related to a reduction in the normal biochemical function of the vitamin thiamine in heart muscle. Inhibition of the a-keto acid dehydrogenase complexes causes accumulation of a-keto acids in heart muscle (and in blood), resulting in a chemically-induced cardiomyopathy. Impairment of two other functions of thiamine may also contribute to the cardiomyopathy. Thiamine pyrophosphate serves as the coenzyme for transketolase in the pentose phosphate pathway, and pentose phosphates accumulate in thiamine deficiency. In addition, thiamine triphosphate (a different coenzyme form) may function in Na conductance channels. [Pg.377]

One of the standard methods for preparing enantiomerically pure compounds is the enantioselective hydrogenation of olefins, a,/3-unsaturated amino acids (esters, amides), a,/3-unsaturated carboxylic acid esters, enol esters, enamides, /3- and y-keto esters etc. catalyzed by chiral cationic rhodium, ruthenium and iridium complexes ". In isotope chemistry, it has only been exploited for the synthesis of e.p. natural and nonnatural H-, C-, C-, and F-labeled a-amino acids and small peptides from TV-protected a-(acylamino)acrylates or cinnamates and unsaturated peptides, respectively (Figure 11.9). This methodology has seen only hmited use, perhaps because of perceived radiation safety issues with the use of hydrogenation procedures on radioactive substrates. Also, versatile alternatives are available, including enantioselective metal hydride/tritide reductions, chiral auxiliary-controlled and biochemical procedures (see this chapter. Sections 11.2.2 and 11.3 and Chapter 12). [Pg.530]


See other pages where Biochemical reductions keto acids is mentioned: [Pg.108]    [Pg.232]    [Pg.98]    [Pg.132]    [Pg.837]    [Pg.426]    [Pg.206]    [Pg.143]    [Pg.102]    [Pg.98]   
See also in sourсe #XX -- [ Pg.143 , Pg.196 ]




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